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La Quinta Pharmacy
   

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La Quinta Pharmacy
43875 Washington St., Suite A
Palm Desert, CA 92211
 

 

Phone:  (760) 777-9902
Fax: (760) 777-9820
Store Hours
Monday - Friday:  9:00 am - 6:00 pm
Saturday: Closed
Sunday: Closed

 

Interested in our other locations?
Fireside Pharmacy
Las Palmas Pharmacy

 

Topical vs. Transdermal Drug Delivery - a function of formulation

Topical
Peripheral tissue activity
Systemic side effects less likely
If analgesic, applied directly over painful site
Insignificant serum levels

Transdermal
Systemic activity
 Potential for adverse effects
If analgesic, may be applied away from painful site
Serum levels necessary for effect

Medications that relieve pain, reduce inflammation, and relax muscles can have side effects that are detrimental to athletic performance, such as drowsiness. However, when these medications are administered topically, the therapeutic benefit can be enhanced while significantly reducing the risk of adverse effects.

For example, research has shown that topically-applied ketoprofen provides a high local concentration of drug below the site of application but decreases systemic exposure and significantly reduces the risk of gastrointestinal upset or bleeding. When properly compounded into an appropriate base, tissue concentrations of ketoprofen were found to be 100-fold greater below the application site (knee) compared to systemic concentrations.  Muscle relaxants can be similarly prepared to minimize the risk of drowsiness.

 

 

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